Understanding T cells in a disease linked to MOG antibodies
Official title: Characterization of T cells in MOG antibody-associated disease
Funded at University of California, San Francisco · NIH-10868714 · Data updated 2026-11-12
This study is looking at how certain immune cells called T cells work with other immune cells in people with MOG antibody-associated disease, which can cause issues like inflammation in the brain and vision problems, to better understand what happens in the body and find new ways to help treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $799,627 |
| NIH project number | 5R01AI170863-02 |
| Project ID | NIH-10868714 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with MOG antibody-associated diseases, such as acute disseminated encephalomyelitis, optic neuritis, or transverse myelitis.
✕Less likely to help
Patients with autoimmune conditions not related to MOG antibodies may not benefit from this research.
What this research studies
This research investigates the role of T cells in MOG antibody-associated disease (MOGAD), which includes conditions like acute disseminated encephalomyelitis and optic neuritis. The study aims to understand how MOG-specific T cells interact with B cells and antibodies to contribute to central nervous system injury. By using a model of experimental autoimmune encephalomyelitis (EAE), researchers will explore the mechanisms of T cell and B cell cooperation in this autoimmune response. The findings could lead to insights into the pathogenesis of MOGAD and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from MOGAD and related autoimmune conditions.
How similar studies have gone: Previous research has shown promising results in understanding T cell and B cell interactions in other autoimmune diseases, suggesting potential for success in this area as well.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Zamvil, Scott S — University of California, San Francisco
- Study coordinator: Zamvil, Scott S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.