Understanding symptom burdens in people with HIV and diabetes/high blood pressure
Official title: Unlocking Hidden Concurrent Symptom Burdens and Estimating Their Associations with Health Outcomes in People Living with HIV and Co-Morbid Diabetes and Hypertension Through Topic Modeling
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11471030 · Data updated 2026-11-12
Researchers will use topic modeling to find common groups of symptoms in people living with HIV, with and without diabetes and hypertension, to see how these symptom groups relate to health outcomes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $234,000 |
| NIH project number | 1R21HL184915-01A1 |
| Project ID | NIH-11471030 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV, with or without co-morbid diabetes and hypertension, across multiple sites.
✕Less likely to help
Patients not experiencing HIV-related symptoms or not contributing data to the identified cohorts may not directly benefit.
What this research studies
This project looks at how multiple symptoms tend to occur together in people living with HIV, especially when diabetes or high blood pressure are also present. Using innovative computer methods (topic modeling), the team will identify latent symptom clusters from patient data across many clinics. They will then examine how these symptom groups relate to important health outcomes to guide better, more targeted symptom management in routine care.
Why it matters
Potential benefit: If successful, findings could help clinicians predict which symptom groups to intervene on first to improve overall health in people with HIV and common co-morbidities.
How similar studies have gone: Prior work on symptom clusters has been limited by small sample sizes; this study aims to overcome that with a large multisite cohort.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Cao, Tru Hoang — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Cao, Tru Hoang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.