Understanding SMARCD3/BAF60C in Medulloblastoma
Role of SMARCD3/BAF60C in medulloblastoma
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11143217
This project explores how a specific gene, SMARCD3, contributes to the growth and spread of medulloblastoma, a type of brain cancer, especially in children.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11143217 on ClinicalTrials.gov |
What this research studies
Medulloblastoma is a fast-growing brain tumor, and for some aggressive types, current treatments are not enough, especially when the cancer spreads or returns. This work focuses on understanding the role of a gene called SMARCD3, which appears to be highly active in the most aggressive forms of medulloblastoma. Researchers believe SMARCD3 helps the tumor grow and spread by influencing other important genes like MYC and P53. By uncovering these molecular secrets, we hope to find new ways to stop these aggressive cancers.
Who could benefit from this research
Good fit: This research is relevant for patients, particularly children aged 0-11, diagnosed with high-risk medulloblastoma, especially Group 3 with MYC amplification or overexpression.
Not a fit: Patients with other types of brain tumors or those whose medulloblastoma does not involve the SMARCD3 pathway may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that specifically target SMARCD3 or its related pathways, offering hope for patients with high-risk medulloblastoma.
How similar studies have performed: This project builds on recent discoveries by the researchers who first identified SMARCD3's role in medulloblastoma metastasis, suggesting a novel approach.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, BAOLI — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: HU, BAOLI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer