Understanding skin interactions in lupus
Official title: Integrated Program for Cutaneous Immune-Stromal Interactions in SLE (IPCISS)
Funded at University of Michigan at Ann Arbor · NIH-11009435 · Data updated 2026-11-12
This study is looking at how skin cells react to sunlight and how that might trigger flare-ups in people with lupus, with the hope of finding safer, personalized treatments to help manage the condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 5, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,540,008 |
| NIH project number | 1P01AI179251-01A1 |
| Project ID | NIH-11009435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing skin-related symptoms.
✕Less likely to help
Patients with other autoimmune conditions not related to skin inflammation may not benefit from this research.
What this research studies
This research investigates how skin cells contribute to the autoimmune disease systemic lupus erythematosus (SLE), particularly focusing on the effects of ultraviolet (UV) light exposure. By examining the interactions between immune and skin cells, the study aims to uncover the mechanisms that lead to skin inflammation and disease flares in SLE patients. The research employs advanced techniques, including multi-omic informatics and ATAC sequencing, to analyze cellular communication and inflammatory responses in the skin. The goal is to develop personalized and non-toxic treatment strategies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with systemic lupus erythematosus.
How similar studies have gone: Previous research has shown promising results in understanding immune interactions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Kahlenberg, Joanne Michelle — University of Michigan at Ann Arbor
- Study coordinator: Kahlenberg, Joanne Michelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.