Understanding skin interactions in lupus
Integrated Program for Cutaneous Immune-Stromal Interactions in SLE (IPCISS)
['FUNDING_P01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11009435
This study is looking at how skin cells react to sunlight and how that might trigger flare-ups in people with lupus, with the hope of finding safer, personalized treatments to help manage the condition.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11009435 on ClinicalTrials.gov |
What this research studies
This research investigates how skin cells contribute to the autoimmune disease systemic lupus erythematosus (SLE), particularly focusing on the effects of ultraviolet (UV) light exposure. By examining the interactions between immune and skin cells, the study aims to uncover the mechanisms that lead to skin inflammation and disease flares in SLE patients. The research employs advanced techniques, including multi-omic informatics and ATAC sequencing, to analyze cellular communication and inflammatory responses in the skin. The goal is to develop personalized and non-toxic treatment strategies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing skin-related symptoms.
Not a fit: Patients with other autoimmune conditions not related to skin inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with systemic lupus erythematosus.
How similar studies have performed: Previous research has shown promising results in understanding immune interactions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAHLENBERG, JOANNE MICHELLE — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KAHLENBERG, JOANNE MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder