Understanding Sex Differences in Brain Cancer
Sex-based Differences in Glioma
This project explores why brain cancer affects men and women differently, aiming to find new ways to help patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11172580 on NIH RePORTER |
What this research studies
This project looks into why glioblastoma, a serious brain cancer, is more common in men and why women tend to live longer after diagnosis. Researchers will examine differences at the molecular and cellular levels to understand these sex-specific patterns. The goal is to uncover specific biological mechanisms that can lead to new, tailored treatments for both male and female patients. This collaborative effort brings together experts to improve our understanding and treatment of glioblastoma.
Who could benefit from this research
Good fit: This research is focused on understanding glioblastoma, so future clinical applications would be relevant to patients diagnosed with this type of brain cancer.
Not a fit: Patients without glioblastoma or other brain cancers would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, personalized treatments for glioblastoma that are specifically designed for men and women, potentially improving patient outcomes.
How similar studies have performed: While sex differences in cancer outcomes are increasingly recognized, this program aims to provide a deeper mechanistic understanding to inform sex-specific therapies, building on prior observations of differences in incidence, outcome, and genetic risk.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lathia, Justin D. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lathia, Justin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.