Understanding severe respiratory infections caused by viruses like SARS-CoV-2
Clinical Phenotyping and Human Core
This study is looking into why some people with severe pneumonia from viruses like COVID-19 and the flu continue to struggle with organ failure and have a higher risk of dying, by examining lung samples to better understand their immune responses and inflammation, which could help find new ways to improve treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10910873 on NIH RePORTER |
What this research studies
This research focuses on severe community-acquired pneumonia (CAP) caused by respiratory viruses, particularly SARS-CoV-2 and influenza. It aims to investigate why some patients experience persistent organ failure and high mortality rates despite treatment. By analyzing bronchoalveolar lavage samples from patients, researchers will study immune responses and inflammation in the lungs to identify potential biomarkers and mechanisms of disease. This approach combines patient samples with findings from animal models to enhance understanding of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with severe pneumonia caused by influenza or SARS-CoV-2 who require intubation.
Not a fit: Patients with mild respiratory infections or those not requiring hospitalization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for patients suffering from severe respiratory infections.
How similar studies have performed: Previous research has shown that understanding immune responses in severe respiratory infections can lead to significant advancements in treatment strategies.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Wunderink, Richard G — Northwestern University at Chicago
- Study coordinator: Wunderink, Richard G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.