Understanding rare genetic variations using roundworms
Official title: EDGE CMT: deleterious recessive variation - from experimental data to predictive models
Funded at New York University · NIH-11014384 · Data updated 2026-11-12
This study is looking at how rare genetic changes in roundworms can influence their traits and health, which might help us understand more about genetic diversity and its effects on living things.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 17, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $333,355 |
| NIH project number | 5R01HG013015-03 |
| Project ID | NIH-11014384 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals with a family history of genetic disorders associated with recessive alleles.
✕Less likely to help
Patients with dominant genetic disorders or those without a known genetic component to their condition may not benefit from this research.
What this research studies
This research investigates how rare genetic variations, specifically recessive alleles, affect biological traits using the roundworm Caenorhabditis becei. By creating a system where these rare alleles can be studied more easily, the researchers aim to measure their effects on fitness and gene expression. The study employs advanced experimental techniques to analyze how these genetic factors interact and contribute to overall genetic diversity. This work could provide insights into the underlying mechanisms of genetic variation and its implications for health.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic disorders linked to recessive alleles, potentially leading to better diagnostic and therapeutic strategies.
How similar studies have gone: Similar research approaches have shown promise in understanding genetic variation, but this specific methodology using C. becei is relatively novel.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Rockman, Matthew — New York University
- Study coordinator: Rockman, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.