Understanding Protein Signals in Cancer
Protein Tyrosine Dephosphorylation & Signal Transduction
This project explores how certain proteins called PTPs work in cancer, hoping to find new ways to create cancer medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11096056 on NIH RePORTER |
What this research studies
Current cancer drugs that target specific proteins often face resistance, so we need new approaches. This project looks at a different group of proteins, called PTPs, which are also important in cancer cell growth. We are trying to understand how these PTPs control signals within cancer cells. By studying these proteins in lab models, we aim to discover new ways to disrupt cancer's growth and overcome drug resistance.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly but aims to benefit individuals with various types of cancer in the future.
Not a fit: Patients seeking immediate new treatments would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new types of cancer treatments, especially for patients who have developed resistance to existing therapies.
How similar studies have performed: While protein tyrosine kinases (PTKs) have been successfully targeted in cancer, developing drugs for protein tyrosine phosphatases (PTPs) has been challenging, making this a novel and important area of focus.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Tonks, Nicholas K — Cold Spring Harbor Laboratory
- Study coordinator: Tonks, Nicholas K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.