Understanding pancreatic function changes before type 1 diabetes develops
Official title: Natural History and Mechanisms of Exocrine Pancreatic Dysfunction in Pre-Type 1 Diabetes
Funded at University of Florida · NIH-10989971 · Data updated 2026-11-12
This study is looking at how the pancreas works in people who might develop type 1 diabetes, especially those who have family members with the condition, to find early signs of pancreatic problems that could help catch diabetes sooner.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $156,168 |
| NIH project number | 5K23DK131363-03 |
| Project ID | NIH-10989971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are first-degree relatives of individuals with type 1 diabetes who may be at risk for developing the condition themselves.
✕Less likely to help
Patients who do not have a family history of type 1 diabetes or those who have already been diagnosed with diabetes may not benefit from this research.
What this research studies
This research investigates how the exocrine function of the pancreas changes in individuals who are at risk of developing type 1 diabetes (T1D). It aims to identify early biomarkers that indicate pancreatic dysfunction before the onset of diabetes. By measuring specific markers in stool and serum, the study will track changes in pancreatic size and function over time in first-degree relatives of T1D patients. This could help in understanding the natural history of T1D and improve early detection methods.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management strategies for individuals at risk of developing type 1 diabetes.
How similar studies have gone: Previous research has shown promise in identifying early biomarkers for type 1 diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Bruggeman, Brittany — University of Florida
- Study coordinator: Bruggeman, Brittany
Related research
Other NIH-funded projects on the same topics.
-
Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
-
Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
-
Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
-
How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
-
Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.