Understanding organ injury caused by pneumonia-related sepsis
Inflammatory Organ Injury after Pneumonia-Derived Sepsis
This study is looking at how pneumonia can cause serious lung problems and other organ damage, especially when caused by tough-to-treat bacteria, and it hopes to find new ways to help protect your lungs and improve treatments for pneumonia and sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-11125931 on NIH RePORTER |
What this research studies
This research investigates how pneumonia-derived sepsis leads to organ injury, particularly focusing on Acute Respiratory Distress Syndrome (ARDS). The study aims to explore the mechanisms behind the body's immune response to infections caused by multidrug-resistant bacteria, specifically targeting the role of a protein called Nrf2 in protecting the lungs. By examining these processes, the research seeks to identify potential new therapies that could reduce damage to the lungs and other organs during severe infections. Patients may benefit from insights that could lead to improved treatment options for pneumonia and sepsis-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced pneumonia or sepsis, particularly those with or at risk for Acute Respiratory Distress Syndrome.
Not a fit: Patients with non-infectious causes of respiratory distress or those who do not have pneumonia or sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce organ injury and improve survival rates for patients suffering from pneumonia-derived sepsis.
How similar studies have performed: While there have been studies on pneumonia and sepsis, this research aims to explore novel approaches to treatment that have not been extensively tested before.
Where this research is happening
Baton Rouge, United States
- Louisiana State Univ A&m Col Baton Rouge — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Jeyaseelan, Samithamby — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Jeyaseelan, Samithamby
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.