Understanding organ injury caused by pneumonia-related sepsis
Official title: Inflammatory Organ Injury after Pneumonia-Derived Sepsis
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-11125931 · Data updated 2026-11-12
This study is looking at how pneumonia can cause serious lung problems and other organ damage, especially when caused by tough-to-treat bacteria, and it hopes to find new ways to help protect your lungs and improve treatments for pneumonia and sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $715,216 |
| NIH project number | 5R01AI180123-02 |
| Project ID | NIH-11125931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced pneumonia or sepsis, particularly those with or at risk for Acute Respiratory Distress Syndrome.
✕Less likely to help
Patients with non-infectious causes of respiratory distress or those who do not have pneumonia or sepsis may not benefit from this research.
What this research studies
This research investigates how pneumonia-derived sepsis leads to organ injury, particularly focusing on Acute Respiratory Distress Syndrome (ARDS). The study aims to explore the mechanisms behind the body's immune response to infections caused by multidrug-resistant bacteria, specifically targeting the role of a protein called Nrf2 in protecting the lungs. By examining these processes, the research seeks to identify potential new therapies that could reduce damage to the lungs and other organs during severe infections. Patients may benefit from insights that could lead to improved treatment options for pneumonia and sepsis-related complications.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce organ injury and improve survival rates for patients suffering from pneumonia-derived sepsis.
How similar studies have gone: While there have been studies on pneumonia and sepsis, this research aims to explore novel approaches to treatment that have not been extensively tested before.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Jeyaseelan, Samithamby — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Jeyaseelan, Samithamby
Related research
Other NIH-funded projects on the same topics.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
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Optimizing Recovery After Sepsis and Pneumonia
A patient-facing program aims to improve recovery for people who survived sepsis and pneumonia after hospital discharge.
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Host-targeted therapy to prevent lung injury from pneumonia-caused sepsis
A patient-focused look at how boosting the body’s own defenses in the lungs could lessen lung and organ damage during severe pneumonia linked to sepsis from bacteria.
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Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
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Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.