Understanding muscle loss and fat reduction in cancer patients
Official title: Mechanisms driving muscle wasting and adipose tissue loss in the UBF mKO mouse
Funded at Oakland University · NIH-11075600 · Data updated 2026-11-12
This study is looking at how cancer can cause muscle loss and weight changes, and how these issues might affect how long patients live, using mice to learn more about the role of certain genes in keeping muscles healthy, which could help find new ways to support people with advanced cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 20, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2024 |
| Award (this year) | $161,910 |
| NIH project number | 3R15AR083675-01S1 |
| Project ID | NIH-11075600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with advanced cancer who are experiencing muscle wasting or cachexia.
✕Less likely to help
Patients with early-stage cancer or those not experiencing significant muscle loss may not benefit from this research.
What this research studies
This research investigates the mechanisms behind muscle wasting and fat loss in cancer patients, particularly focusing on how these changes affect survival rates. By studying a specific mouse model, researchers aim to uncover the role of ribosome biogenesis in maintaining muscle mass and preventing atrophy. The approach involves manipulating genetic factors to observe their impact on muscle health, which could lead to new therapeutic strategies for improving outcomes in advanced cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help maintain muscle mass in cancer patients, potentially improving their survival and quality of life.
How similar studies have gone: Previous research has shown promising results in targeting muscle mass preservation in cancer models, indicating that this approach has potential for success.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Figueiredo, Vandre Casagrande — Oakland University
- Study coordinator: Figueiredo, Vandre Casagrande
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.