Understanding Mitochondria's Role in Health and Disease
Evolution-guided Studies of Mitochondrial Functions
This project explores how our cells' powerhouses, called mitochondria, function and respond to threats like viruses, which could offer new insights into autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11229379 on NIH RePORTER |
What this research studies
This project uses an innovative approach to discover how genes work by studying the interactions between our bodies and viruses. Researchers are particularly interested in mitochondria, the energy-producing parts of our cells, and how they respond to stress and infection. By identifying new ways viruses might target mitochondria, the team hopes to uncover fundamental cellular processes. This work involves using advanced computer analysis and laboratory tests to map out these complex interactions. The goal is to build a comprehensive understanding that could eventually lead to new ways to address conditions like autoimmune diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical studies stemming from this work might seek patients with specific autoimmune conditions.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could reveal new cellular pathways and targets for future treatments, potentially leading to better therapies for autoimmune diseases.
How similar studies have performed: The approach of using host-virus interactions to discover gene functions has previously led to important discoveries about fundamental cellular processes and key regulators like P53.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Hancks, Dustin — Ut Southwestern Medical Center
- Study coordinator: Hancks, Dustin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.