Understanding metabolic changes in infants after heart surgery
Metabolic profiling and comprehensive metabolic pathway mapping: a systems biology approach to cardiovascular failure and organ injury following infant congenital heart disease surgery
This study is looking at how heart surgery affects the metabolism of infants, especially those who need a heart-lung machine, to find ways to spot problems early and improve their recovery after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11074648 on NIH RePORTER |
What this research studies
This research investigates how metabolic changes occur in infants who undergo heart surgery, particularly those requiring cardiopulmonary bypass. By analyzing the metabolites in the blood and tissues of these infants, the study aims to identify patterns that could indicate complications and improve postoperative care. The approach involves comprehensive metabolic profiling and pathway mapping to understand the physiological impacts of surgery on these young patients. The findings could lead to better diagnostic and therapeutic strategies for managing postoperative outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants under 12 months old who are scheduled to undergo surgery for congenital heart disease.
Not a fit: Patients who are not undergoing cardiac surgery or who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for infants recovering from heart surgery, potentially reducing complications and hospital stays.
How similar studies have performed: Previous research has shown promising results in understanding metabolic profiles in similar surgical contexts, indicating potential for success in this approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Davidson, Jesse — University of Colorado Denver
- Study coordinator: Davidson, Jesse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.