Understanding mental health and cognitive issues in people living with HIV in Uganda
Official title: Mental Health and Cognition in HIV Infection in Rakai Uganda
Funded at Johns Hopkins University · NIH-10663076 · Data updated 2026-11-12
This study is looking at how depression and thinking problems affect people living with HIV in Uganda, even when they are getting treatment, and it hopes to find out what specific challenges they face so that better support can be provided.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 22, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $578,547 |
| NIH project number | 5R01MH120693-05 |
| Project ID | NIH-10663076 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV in Uganda who may be experiencing mental health disorders or cognitive impairments.
✕Less likely to help
Patients living with HIV outside of Uganda or those without mental health concerns may not benefit from this research.
What this research studies
This research investigates the mental health disorders, particularly depression and neurocognitive impairment, that affect individuals living with HIV in Uganda, despite their treatment with antiretroviral therapy. It aims to explore the unique psychosocial factors contributing to these mental health issues in a low-income setting, where common confounding factors seen in wealthier countries are less prevalent. By employing a novel framework that recognizes the diversity of mental health conditions, the study will analyze behavioral phenotypes and their functional consequences. The findings could lead to better-targeted interventions for mental health in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved mental health care and interventions for individuals living with HIV in Uganda.
How similar studies have gone: Previous research has shown that addressing mental health in HIV populations can lead to significant improvements in patient outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Rubin, Leah Helane — Johns Hopkins University
- Study coordinator: Rubin, Leah Helane
Related research
Other NIH-funded projects on the same topics.
-
How different kinds of screen time affect kids' mental health and brain development
This project looks at how types of screen use like video games, TV, and social media relate to children's thinking, emotions, and brain changes as they grow from about age 10 into early adulthood.
-
Understanding how screen media affects mental health and brain development in children and adolescents
This study looks at how different types of screen time, like playing video games and using social media, affect the mental health and brain development of kids and teens aged 10 to 20, helping us understand what kinds of screen activities might be good or bad for them.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
-
Adolescent girls in Uganda: a long-term look at how money empowerment and family support affect HIV prevention, care, and mental health
A long-term study in rural Uganda will test whether an intervention that combines economic empowerment and family strengthening can help HIV-negative and HIV-affected adolescent girls move safely into young adulthood.
-
Long-term HIV prevention and mental health support for adolescent girls and young women in Uganda
A long-term program in rural Uganda tests if combining economic support and family strengthening helps teenage girls stay HIV-free and improve mental health as they grow into young adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.