Understanding lung transplantation and its complications using mouse models
Core C: Mouse and Cell Phenotyping Core
This study is working on creating better mouse models to understand problems that can happen after lung transplants, like early and long-term complications, so that researchers can find new ways to improve treatment for patients who receive lung transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10933922 on NIH RePORTER |
What this research studies
This research focuses on developing reliable mouse models to study lung transplantation, specifically looking at complications like primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD). By utilizing advanced technologies for phenotyping, the research aims to uncover the molecular pathways involved in these complications and assess how different therapeutic strategies affect outcomes. The findings will be shared with the broader research community to enhance understanding and treatment of lung transplant issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received or are considering lung transplants and may be at risk for complications like PGD or CLAD.
Not a fit: Patients who are not candidates for lung transplantation or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for patients undergoing lung transplantation.
How similar studies have performed: Previous research has shown success in using mouse models to study transplantation complications, indicating that this approach is both established and promising.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Ridge, Karen M — Northwestern University at Chicago
- Study coordinator: Ridge, Karen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.