Understanding long-term outcomes for young people at risk of psychosis

Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis

NIH-funded research University of California, San Diego · NIH-10847464

This study is looking at young people aged 12-20 who are at risk of developing serious mental health issues, to see what factors might help predict whether they will experience these challenges in the future, so we can better understand how to support them.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego NIH-funded
Lab location1 site (La Jolla, United States)
Project IDNIH-10847464 on NIH RePORTER

What this research studies

This research investigates the long-term outcomes of adolescents aged 12-20 who are identified as being at clinical high risk for developing psychosis. It aims to identify predictors and moderators that influence whether these individuals will progress to full-blown psychotic disorders. The study utilizes a combination of clinical assessments, biological markers, and neurocognitive evaluations to track changes over time. By following participants over several years, the research seeks to uncover the dynamics of psychosis development and the factors that may contribute to better or worse outcomes.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents aged 12-20 who are showing early signs of psychosis or are identified as being at clinical high risk.

Not a fit: Patients who are not within the age range of 12-20 or who do not exhibit any signs of being at clinical high risk for psychosis may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved early interventions and tailored treatments for young individuals at risk of psychosis.

How similar studies have performed: Previous research has shown promising results in understanding the predictors of psychosis in high-risk populations, indicating that this approach has potential for significant insights.

Where this research is happening

La Jolla, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Chronic Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.