Understanding kidney injury caused by medications in veterans
Official title: Nephrotoxic Acute Kidney Injury in Veterans
Funded at Iowa City VA Medical Center · NIH-11048705 · Data updated 2026-11-12
This study is looking at how certain medications can harm the kidneys in veterans, and it aims to find out which patients are most at risk so we can help prevent kidney problems before they happen.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| NIH project number | 1IK2BX006525-01A1 |
| Project ID | NIH-11048705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who are 21 years or older and are at risk of acute kidney injury due to nephrotoxic medications.
✕Less likely to help
Patients who are not veterans or those who do not have risk factors for acute kidney injury may not benefit from this research.
What this research studies
This research investigates acute kidney injury (AKI) in veterans, particularly focusing on cases caused by nephrotoxic medications. It aims to identify patients at high risk for this condition using advanced machine learning techniques to analyze various patient and medication data. The study seeks to improve prevention strategies, as there are currently no specific treatments for AKI once it occurs. By understanding the factors leading to nephrotoxic AKI, the research hopes to enhance patient outcomes and reduce the incidence of long-term complications.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for acute kidney injury in veterans, ultimately improving their long-term health outcomes.
How similar studies have gone: Previous research has shown promise in using machine learning to predict and prevent acute kidney injury, indicating that this approach could be effective.
Where this research is happening
-
Iowa City VA Medical Center
Iowa City, United States Active
Researchers
- Principal investigator: Griffin, Benjamin R — Iowa City VA Medical Center
- Study coordinator: Griffin, Benjamin R
Related research
Other NIH-funded projects on the same topics.
-
SEAK Alliance: Improving Care for AKI Patients in the Southeast
A national, patient-centered effort to improve post-hospital care for people who had acute kidney injury in the Southeast.
-
AKI-related delirium after heart surgery
This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.
-
Better ways to identify types of sudden kidney injury in U.S. Veterans
Researchers are looking for genetic and health patterns that define different types of sudden severe kidney injury in Veterans to help guide future care.
-
Neuroimmune control of kidney injury using noninvasive ultrasound
A new approach uses targeted ultrasound to gently stimulate nerves and immune signals to help the kidney recover after injury.
-
Structure-based approach to prevent kidney injury from polymyxin use
Aims to block how polymyxin damages the kidney so it can be used more safely to treat hard-to-kill infections.
-
Using smart computer predictions to prevent kidney injury after heart surgery
A machine-learning approach uses routinely collected hospital data to predict who might develop acute kidney injury after heart surgery, so clinicians can act early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.