Understanding kidney inflammation in lupus nephritis
Official title: Project 1 - BIDMC
Funded at Beth Israel Deaconess Medical Center · NIH-11046583 · Data updated 2026-11-12
This study is looking at how kidney cells react to the immune system issues in people with lupus, especially those with kidney problems, to find better ways to treat them and improve their care.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $685,464 |
| NIH project number | 5P01AI179405-02 |
| Project ID | NIH-11046583 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those who have developed or are at risk for lupus nephritis.
✕Less likely to help
Patients without systemic lupus erythematosus or those whose kidney issues are unrelated to autoimmune conditions may not benefit from this research.
What this research studies
This research investigates how kidney cells respond to autoimmune elements in patients with systemic lupus erythematosus (SLE), particularly focusing on lupus nephritis (LN). By examining the molecular changes in kidney resident cells, the study aims to identify reliable biomarkers and develop targeted treatment approaches. The research utilizes advanced techniques to analyze urine podocytes and tubular epithelial cells, which may reflect the underlying kidney damage. The ultimate goal is to improve treatment precision for patients suffering from LN.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for patients with lupus nephritis, minimizing side effects and improving outcomes.
How similar studies have gone: Previous research has shown promise in understanding autoimmune responses in lupus, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Tsokos, George C — Beth Israel Deaconess Medical Center
- Study coordinator: Tsokos, George C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.