Understanding inflammatory skin injury from vesicants using spatial omics
Official title: Integrated spatial omics to elucidate conserved inflammatory mechanisms of vesicant-induced skin injury
Funded at University of Texas Med Br Galveston · NIH-11392471 · Data updated 2026-11-12
A patient-friendly look at how scientists study skin burns from chemical vesicants to find ways to reduce damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $183,320 |
| NIH project number | 5R34AR084669-03 |
| Project ID | NIH-11392471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants would be individuals with vesicant-related burn injuries or samples from such injuries when applicable.
✕Less likely to help
Patients without vesicant-related burns or non-skin burn injuries may not directly benefit from this specific study.
What this research studies
This project uses advanced spatial omics to map where and how inflammation happens in skin after vesicant exposure, aiming to identify common targets for treatment. It emphasizes early anti-inflammatory strategies to limit tissue damage within 72 hours of exposure. The work combines tissue analysis with modern imaging to keep the spatial context of inflammation, potentially guiding new countermeasures that work across different vesicants. The study is centered on the biology of burn injuries and how to translate findings into therapies that can help patients who suffer chemical-related skin burns.
Why it matters
Potential benefit: If successful, the research could speed up development of broad-spectrum treatments that limit skin damage after vesicant exposure.
How similar studies have gone: Similar approaches using spatial information in tissue analysis have shown promise in understanding localized inflammatory responses.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Prideaux, Brendan — University of Texas Med Br Galveston
- Study coordinator: Prideaux, Brendan
Related research
Other NIH-funded projects on the same topics.
-
HPV and pregnancy risk: a big study following 1,280 pregnancies
A large pregnancy study at UTMB looks at whether human papillomavirus (HPV) during pregnancy is linked to problems like preterm birth.
-
West African Center for Emerging Infectious Diseases
A national West African collaboration is studying how dangerous viruses spread between animals and people, with the goal of improving prevention and response.
-
West African Center for Emerging Infectious Diseases
A multi-country program in West Africa aims to better understand how emerging infectious diseases spread from animals to people and how to prevent outbreaks that could affect the U.S.
-
West Africa Center for Emerging Infectious Diseases
A patient-facing center in West Africa studies how emerging viruses spread to people and livestock so we can better protect communities and prevent outbreaks.
-
West African Center for Emerging Infectious Diseases
Aiming to understand and prevent emerging viruses in West Africa to protect people in the U.S. and globally.
-
West Africa Center for Emerging Infectious Diseases
A US-funded center in West Africa aims to better understand and prevent outbreaks of deadly viruses by studying how diseases spread between animals, people, and the environment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.