Understanding inflammation after trauma and infection
Official title: BLRD Research Career Scientist Award Application
Funded at Veterans Health Administration · NIH-11105802 · Data updated 2026-11-12
This study is looking into how trauma and infections can cause serious lung problems and inflammation in the body, with the goal of finding ways to help prevent these issues in veterans who have gone through tough injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5IK6BX006297-03 |
| Project ID | NIH-11105802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who have experienced significant trauma or sepsis and are at risk for developing SIRS or ALI.
✕Less likely to help
Patients who have not experienced trauma or sepsis may not benefit from this research.
What this research studies
This research focuses on the cellular and molecular mechanisms that lead to systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) following trauma and sepsis. By investigating how these conditions develop, the research aims to identify specific targets for prophylactic interventions that could prevent complications in patients who have survived initial injuries. The work is particularly relevant for veterans, as they often experience these severe health issues after traumatic events. The research employs a combination of laboratory studies and clinical insights to explore these complex biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing serious complications in patients recovering from trauma and sepsis.
How similar studies have gone: Previous research has shown promise in understanding inflammation mechanisms, but this specific approach is aimed at a particularly challenging area and may provide novel insights.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Fan, Jie — Veterans Health Administration
- Study coordinator: Fan, Jie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.