Understanding immune system diversity in the Eastern Hemisphere
Evolution and Function of Immunogenetic Diversity across the Eastern Hemisphere
This study is looking at how certain genes related to our immune system can differ among people and how these differences might affect our health, especially in conditions like autoimmune diseases and cancer, to help improve treatments and organ matching for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10884489 on NIH RePORTER |
What this research studies
This research investigates the variations in human leukocyte antigens (HLA) and killer cell immunoglobulin-like receptors (KIR), which are essential components of the immune system. By studying a diverse group of over 15,000 individuals from various populations across the Eastern Hemisphere, the project aims to uncover how these genetic variations affect immune responses and their links to diseases such as autoimmunity and cancer. The research employs advanced bioinformatics and CRISPR methodologies to analyze genetic data and understand the functional implications of these immune variations. This knowledge could lead to improved personalized medicine and better matching of organ donors with recipients.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals from diverse populations in the Eastern Hemisphere, particularly those with autoimmune diseases or related health issues.
Not a fit: Patients who do not belong to the studied populations or those without autoimmune diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance the development of personalized immunotherapies and improve outcomes for patients with autoimmune diseases and other immune-related conditions.
How similar studies have performed: Previous research has shown success in understanding immune diversity through genetic studies, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Norman, Paul John — University of Colorado Denver
- Study coordinator: Norman, Paul John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.