Understanding Immune System Changes in Type 1 Diabetes
Immune Function and the Progression to Type 1 Diabetes
This research explores how changes in the body's immune system contribute to the development of Type 1 diabetes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11091574 on NIH RePORTER |
What this research studies
Our bodies have an immune system that normally protects us from illness, but in Type 1 diabetes, it mistakenly attacks the cells in the pancreas that make insulin. This project looks closely at how specific genetic differences influence these immune system problems. We want to understand the exact ways these genetic factors, along with cellular stress, lead to the destruction of insulin-producing cells. By uncovering these mechanisms, we hope to find new ways to prevent or treat Type 1 diabetes.
Who could benefit from this research
Good fit: This research is foundational and focuses on understanding disease mechanisms, so it is most relevant to individuals with Type 1 diabetes or those at increased genetic risk for the condition.
Not a fit: Patients without Type 1 diabetes or a genetic predisposition to it would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Type 1 diabetes, potentially paving the way for new strategies to prevent its onset or halt its progression.
How similar studies have performed: Previous studies supported by this grant have already identified numerous immune abnormalities and genetic links to Type 1 diabetes, indicating a strong foundation for this ongoing work.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Brusko, Todd Michael — University of Florida
- Study coordinator: Brusko, Todd Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.