Understanding immune responses in children with severe respiratory distress
Official title: Longitudinal Analysis of Blood and Airway Immune Response: Precision Medicine for
Funded at Emory University · NIH-11020989 · Data updated 2026-11-12
This study is looking at how the immune system, especially a type of white blood cell called neutrophils, behaves in children with severe breathing problems caused by pediatric acute respiratory distress syndrome (PARDS), to help find better treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $474,078 |
| NIH project number | 5R01HL171627-02 |
| Project ID | NIH-11020989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are experiencing or are at risk for pediatric acute respiratory distress syndrome.
✕Less likely to help
Patients who do not have respiratory distress or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates how the immune system, particularly neutrophils, responds in children suffering from pediatric acute respiratory distress syndrome (PARDS). By analyzing blood and airway samples over time, the study aims to uncover the mechanisms that lead to severe outcomes in affected children. The research focuses on understanding how neutrophil death contributes to lung injury and poor clinical outcomes, which could help tailor treatments for these patients. Participants will be closely monitored to assess their immune responses and overall health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for children suffering from severe respiratory distress.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in respiratory conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Grunwell, Jocelyn Rebecca — Emory University
- Study coordinator: Grunwell, Jocelyn Rebecca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.