Understanding immune dysfunction in sepsis and its treatment
Metabolic and purinergic immune regulation
This study is looking at how sepsis affects the immune system and aims to find new ways to help patients by understanding how certain immune cells work, so we can improve treatments for this serious condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10880418 on NIH RePORTER |
What this research studies
This research investigates the immune dysfunction associated with sepsis, a severe condition that can lead to multiple organ failure and death. The team aims to uncover the molecular and cellular mechanisms that contribute to both excessive inflammation and immunosuppression in sepsis patients. By studying how immune cells, particularly neutrophils and T cells, are regulated through novel signaling pathways, the researchers hope to identify new pharmacological strategies to restore immune balance and improve patient outcomes. This work is crucial as current treatments for sepsis have not been effective.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with sepsis or those at high risk of developing sepsis due to trauma or critical illness.
Not a fit: Patients with non-infectious causes of immune dysfunction or those not experiencing sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates and recovery for patients suffering from sepsis.
How similar studies have performed: While there have been numerous studies on sepsis, this research aims to explore novel mechanisms that have not been extensively tested, making it a potentially groundbreaking approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Junger, Wolfgang G — University of California, San Diego
- Study coordinator: Junger, Wolfgang G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.