Understanding Immune Cells in Heart and Kidney Disease for Type 1 Diabetes
Immunometabolism and the Cardio-Renal Axis in T1D-associated Atherosclerosis: Insights from the CaRe T1D Biobank
This project looks at how immune cells contribute to heart and kidney problems in people with type 1 diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11194419 on NIH RePORTER |
What this research studies
Cardiovascular disease, often caused by atherosclerosis, is a major concern for individuals with type 1 diabetes. While we know immune cells called T cells attack insulin-producing cells in diabetes, we don't fully understand their role in heart complications. This work uses samples from a special biobank to explore how specific T cells gather in blood vessels and kidneys, potentially worsening heart disease in type 1 diabetes. We aim to uncover the specific types of T cells involved and how they might contribute to the increased risk of heart and kidney issues.
Who could benefit from this research
Good fit: This research is relevant to individuals with type 1 diabetes who are at risk for or have developed cardiovascular disease or kidney complications.
Not a fit: Patients without type 1 diabetes or related cardiovascular and kidney complications would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat heart and kidney disease in people with type 1 diabetes by targeting specific immune cells.
How similar studies have performed: While the role of T cells in diabetes is known, this specific approach to dissecting their role in T1D-associated atherosclerosis using advanced sequencing of biobank samples is a novel and focused line of inquiry.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Bornfeldt, Karin E — University of Washington
- Study coordinator: Bornfeldt, Karin E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.