Understanding immune cell dysfunction in patients recovering from sepsis
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology
This study is looking into why some people who survive sepsis don’t fully get better, focusing on certain immune cells that might be causing problems, and it’s for patients who want to understand more about their recovery after sepsis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11077756 on NIH RePORTER |
What this research studies
This research investigates why some patients who survive sepsis do not fully recover, focusing on the role of specific immune cells called myeloid-derived suppressor cells (MDSCs). The study aims to understand how these cells expand and affect the immune response in patients after surgical sepsis. By examining the underlying mechanisms of dysfunctional myelopoiesis, the research seeks to identify why certain patients experience poor long-term outcomes despite receiving optimal care. The approach includes analyzing blood samples and immune cell behavior in affected individuals to uncover potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone surgery and experienced sepsis, particularly those struggling with long-term recovery.
Not a fit: Patients who have not experienced sepsis or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery and quality of life for sepsis survivors.
How similar studies have performed: Previous research has shown promising results in understanding immune dysfunction in sepsis, but this specific approach focusing on MDSCs is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Efron, Philip a — University of Florida
- Study coordinator: Efron, Philip a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.