Understanding immune cell changes in type 1 diabetes
Dissecting transcriptomics and epigenomic signatures of immune cells in type 1 diabetes
['FUNDING_U01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10829819
This study is looking at how immune cells might play a role in type 1 diabetes by exploring the genetic changes that happen in these cells, with the hope of finding early signs of the disease and new ways to help patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10829819 on ClinicalTrials.gov |
What this research studies
This research investigates how immune cells contribute to type 1 diabetes (T1D) by examining the genetic and molecular changes that occur in these cells. It focuses on the role of genetic variations in regulating gene expression and how these changes may lead to the destruction of insulin-producing cells in the pancreas. By analyzing immune cells from human pancreatic tissues, the study aims to identify early signs of T1D and improve our understanding of the disease's progression. Patients may benefit from insights that could lead to new diagnostic tools or therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of type 1 diabetes or those showing early signs of autoimmune activity against pancreatic cells.
Not a fit: Patients who are already diagnosed with advanced type 1 diabetes and have significant complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better treatment options for individuals at risk of developing type 1 diabetes.
How similar studies have performed: Other research has shown promise in understanding autoimmune diseases through genetic and molecular profiling, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAHEDI, GOLNAZ — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: VAHEDI, GOLNAZ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease