Understanding immune aging in individuals with Down syndrome
Mechanistic and functional dissection of inflammaging in Down syndrome
This study is looking at how the immune system ages faster in people with Down syndrome and how this affects their health, with the goal of finding ways to help improve their immune function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10908301 on NIH RePORTER |
What this research studies
This research investigates how the immune system ages prematurely in individuals with Down syndrome, a phenomenon known as inflammaging. It focuses on the role of naïve CD4+ T cells and how their dysregulation contributes to immune system impairments. By analyzing immune architecture, the study aims to uncover the mechanisms behind increased autoimmunity and other health risks associated with Down syndrome. The findings could lead to new therapeutic strategies to improve immune function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those experiencing immune-related health issues.
Not a fit: Patients without Down syndrome or those who do not exhibit signs of immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immune health and better treatment options for individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding immune aging in other populations, suggesting potential for success in this novel approach.
Where this research is happening
Seattle, United States
- Benaroya Research Inst at Virginia Mason — Seattle, United States (Active)
Researchers
- Principal investigator: Khor, Bernard — Benaroya Research Inst at Virginia Mason
- Study coordinator: Khor, Bernard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.