Understanding HPV and cervical health in vaccinated youth with HIV
Natural History of CIN and HPV in HPV Vaccinated Youth with PHIV
This study is looking at how the HPV vaccine helps young people with perinatal HIV infection stay healthy, especially regarding their cervical health and HPV levels, so we can learn more about their needs compared to those who aren't infected.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897168 on NIH RePORTER |
What this research studies
This research investigates how the HPV vaccine affects youth with perinatal HIV infection (PHIV) in terms of their cervical health and the persistence of HPV. It aims to determine the natural history of cervical intraepithelial neoplasia (CIN) in these individuals, particularly focusing on the rates of abnormal cytology and HPV antibody levels compared to uninfected peers. The study will involve screening participants with abnormal cytology through colposcopy and HPV genotyping to better understand the implications of vaccination in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research include youth aged 0-21 who have been vaccinated against HPV and are living with perinatal HIV infection.
Not a fit: Patients who are not vaccinated against HPV or do not have perinatal HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cervical cancer prevention strategies for youth with PHIV.
How similar studies have performed: Previous studies have indicated challenges in HPV vaccination efficacy among HIV-infected populations, suggesting that this research addresses a critical and underexplored area.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Moscicki, Anna-Barbara — Harvard School of Public Health
- Study coordinator: Moscicki, Anna-Barbara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.