Understanding how YTHDF3 affects heart function
Official title: YTHDF3 as a critical regulator of cardiac function
Funded at Ohio State University · NIH-10898620 · Data updated 2026-11-12
This study is looking at how a protein called YTHDF3 affects heart cells and could help us understand better ways to treat heart failure by exploring how changes in messenger RNA impact heart recovery after injury.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $44,224 |
| NIH project number | 5F30HL165812-02 |
| Project ID | NIH-10898620 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who are experiencing or at risk for heart failure or related cardiac conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of YTHDF3, a protein that regulates gene expression in heart cells, particularly in the context of heart failure. The study aims to uncover how modifications to messenger RNA (mRNA) influence cardiac remodeling after injury, which can lead to heart failure. By examining the mechanisms behind these processes, the research seeks to identify potential new therapies for heart conditions. Patients may benefit from insights gained about how to better manage or treat heart diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart failure.
How similar studies have gone: Previous research has shown promising results in understanding mRNA modifications in cardiac function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Rabolli, Charles P. — Ohio State University
- Study coordinator: Rabolli, Charles P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.