Understanding how X-chromosomes are turned off and regulated by special genetic instructions
Regulation of X-chromosome inactivation and imprinting by non-coding elements
This work explores how one of the two X-chromosomes in females becomes inactive, a process that is crucial for healthy development and can impact conditions like cancer and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11088745 on NIH RePORTER |
What this research studies
Our bodies have special instructions called non-coding RNAs that help control important processes, like turning off one of the X-chromosomes in females. This process, called X-chromosome inactivation, ensures the right balance of genetic material and can happen randomly or in a specific, inherited way. We are learning how different parts of the X-chromosome work together to decide which X-chromosome gets turned off. This includes understanding how certain RNAs act as 'on' or 'off' switches and how the X-chromosomes communicate with each other. Our goal is to uncover the fundamental rules governing this essential biological process.
Who could benefit from this research
Good fit: This foundational biological work does not directly involve patient participation, but it is relevant to individuals with conditions potentially influenced by X-chromosome inactivation, such as certain cancers or atherosclerotic cardiovascular disease.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge about genetic regulation, which may lead to a better understanding of diseases linked to X-chromosome function, such as certain cancers and cardiovascular conditions.
How similar studies have performed: Our ongoing work has already advanced the understanding of X-chromosome inactivation mechanisms, building on previous successful findings in this field.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lee, Jeannie T — Massachusetts General Hospital
- Study coordinator: Lee, Jeannie T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.