Understanding how X-chromosome inactivation affects systemic sclerosis
Elucidating the Role of Dynamic X-Chromosome Inactivation Maintenance in the Pathogenesis of Systemic Sclerosis
This study is looking at how a process called X-chromosome inactivation might play a role in systemic sclerosis, a condition that mainly affects women, by examining how it impacts the immune system and tissue scarring, and it invites patients to help by sharing samples or information to better understand these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10703419 on NIH RePORTER |
What this research studies
This research investigates the role of X-chromosome inactivation in systemic sclerosis, a serious autoimmune disease that primarily affects women. It explores how the dynamic maintenance of this epigenetic process may contribute to the disease's development, particularly in relation to immune system dysfunction and fibrosis. By examining T-cells and their behavior in this context, the research aims to uncover new insights into the underlying mechanisms of systemic sclerosis. Patients may be involved in providing samples or data to help elucidate these complex biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation are women diagnosed with systemic sclerosis or those at risk due to genetic factors.
Not a fit: Patients with autoimmune diseases other than systemic sclerosis may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for systemic sclerosis, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic mechanisms in autoimmune diseases, suggesting potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Anguera, Montserrat C — University of Pennsylvania
- Study coordinator: Anguera, Montserrat C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.