Understanding how vitamin E and its transport protein affect liver and nervous system health
Functions of vitamin E and the tocopherol transfer protein
This study is looking at how vitamin E helps keep your brain and liver healthy, especially by understanding how it moves through your body and what happens if you don't get enough of it, using mice to learn more about its benefits.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10766695 on NIH RePORTER |
What this research studies
This research investigates the role of alpha-tocopherol (vitamin E) and its transport protein in maintaining health, particularly focusing on how vitamin E protects the central nervous system from damage. The study will explore the molecular mechanisms that allow vitamin E to be transported from the liver to various tissues and how deficiencies in this process can lead to neurological disorders. Using mouse models, researchers will also examine the antioxidant-independent effects of vitamin E on liver health and its potential to prevent liver disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver disorders or genetic mutations affecting vitamin E metabolism.
Not a fit: Patients without liver disorders or those not affected by vitamin E deficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver disorders and neurological diseases linked to vitamin E deficiency.
How similar studies have performed: Previous research has shown promising results in understanding the role of vitamin E in health, but this specific approach to studying its transport mechanisms is relatively novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Manor, Danny — Case Western Reserve University
- Study coordinator: Manor, Danny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.