Understanding how viruses use lipids to replicate
Official title: Manipulation of lipid metabolism in (+)RNA virus replication
Funded at University of Chicago · NIH-11094809 · Data updated 2026-11-12
This study looks at how some viruses change the fats in our cells to help them multiply, and it hopes to find new ways to create treatments that can stop these viruses from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 7, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $410,000 |
| NIH project number | 5R01AI173337-03 |
| Project ID | NIH-11094809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals infected with (+) RNA viruses, such as those causing hepatitis C or other related viral infections.
✕Less likely to help
Patients with non-viral infections or those not affected by (+) RNA viruses may not receive any benefit from this research.
What this research studies
This research investigates how certain viruses manipulate the lipids in cell membranes to create environments that support their replication. By focusing on the endoplasmic reticulum, the study aims to uncover the mechanisms by which viral proteins alter lipid composition, particularly phosphatidyl choline, to enhance viral replication. The research involves detailed biochemical assays and cellular models to define the roles of specific enzymes and lipids in the viral life cycle. Patients may benefit from insights gained that could lead to new antiviral therapies targeting these processes.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral treatments that disrupt viral replication mechanisms.
How similar studies have gone: Other research has shown promising results in targeting lipid metabolism for antiviral strategies, indicating that this approach may be viable.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Randall, Glenn C — University of Chicago
- Study coordinator: Randall, Glenn C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.