Understanding how viruses interact with the immune response during COVID-19.
Identifying the targets of virus-induced PARPs during SARS-CoV-2 infection
This study is looking at how certain proteins in our body, called PARPs, help our immune system fight off the COVID-19 virus, with the goal of finding new ways to improve our body's response to the infection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project ID | NIH-10753577 on NIH RePORTER |
What this research studies
This research investigates the role of poly-ADP-ribose polymerases (PARPs) in the immune response to SARS-CoV-2 infection. It aims to identify which PARPs are involved in combating the virus and how they modify viral and host proteins to limit virus replication. By studying these interactions, the research seeks to uncover the mechanisms that determine the severity of COVID-19 and the effectiveness of the immune response. This could lead to new therapeutic strategies to enhance the body's ability to fight off the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with SARS-CoV-2 or are at high risk of infection.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with unrelated viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for COVID-19 by enhancing the immune response against the virus.
How similar studies have performed: Other research has shown promising results in understanding viral interactions with the immune system, suggesting that this approach could yield valuable insights.
Where this research is happening
Lawrence, United States
- University of Kansas Lawrence — Lawrence, United States (Active)
Researchers
- Principal investigator: Fehr, Anthony R — University of Kansas Lawrence
- Study coordinator: Fehr, Anthony R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.