Understanding how viruses interact with the immune response during COVID-19.
Official title: Identifying the targets of virus-induced PARPs during SARS-CoV-2 infection
Funded at University of Kansas Lawrence · NIH-10753577 · Data updated 2026-11-12
This study is looking at how certain proteins in our body, called PARPs, help our immune system fight off the COVID-19 virus, with the goal of finding new ways to improve our body's response to the infection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project start | December 12, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $186,159 |
| NIH project number | 5R21AI173781-02 |
| Project ID | NIH-10753577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been infected with SARS-CoV-2 or are at high risk of infection.
✕Less likely to help
Patients who have not been infected with SARS-CoV-2 or those with unrelated viral infections may not benefit from this research.
What this research studies
This research investigates the role of poly-ADP-ribose polymerases (PARPs) in the immune response to SARS-CoV-2 infection. It aims to identify which PARPs are involved in combating the virus and how they modify viral and host proteins to limit virus replication. By studying these interactions, the research seeks to uncover the mechanisms that determine the severity of COVID-19 and the effectiveness of the immune response. This could lead to new therapeutic strategies to enhance the body's ability to fight off the virus.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for COVID-19 by enhancing the immune response against the virus.
How similar studies have gone: Other research has shown promising results in understanding viral interactions with the immune system, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kansas Lawrence
Lawrence, United States Active
Researchers
- Principal investigator: Fehr, Anthony R — University of Kansas Lawrence
- Study coordinator: Fehr, Anthony R
Related research
Other NIH-funded projects on the same topics.
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How COVID-19 infection and genes may influence memory and dementia risk
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Alzheimer’s-related dementia after COVID-19: how SARS-CoV-2 affects the brain and potential drug repurposing
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-
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Maternal SARS-CoV-2 infection and its effects on placenta and child development
This grant studies how COVID-19 infection during pregnancy might change the placenta and influence a child’s brain development, especially in kids who may be at higher genetic risk for ADHD/ASD.
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How COVID-19 and genetics influence memory and dementia risk in older adults
This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.
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This project in Kenya checks how having had COVID-19 might influence the reactivation of latent tuberculosis in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.