Understanding how TXLNA affects immune responses to DNA
Official title: Role of TXLNA in cytosolic DNA-mediated innate immunity
Funded at Tulane University of Louisiana · NIH-11094198 · Data updated 2026-11-12
This study is looking at a protein called TXLNA to see how it helps our immune system respond to germs, and it’s especially for people interested in understanding autoimmune diseases like lupus and finding new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | June 20, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $382,500 |
| NIH project number | 1R01AI189439-01 |
| Project ID | NIH-11094198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases, particularly systemic lupus erythematosus, or those undergoing cancer immunotherapy.
✕Less likely to help
Patients with non-autoimmune conditions or those not involved in cancer treatment may not benefit from this research.
What this research studies
This research investigates the role of a protein called TXLNA in the immune system's response to DNA from pathogens. It focuses on how TXLNA interacts with other proteins involved in the cGAS-STING signaling pathway, which is crucial for producing immune responses. By using a special mouse model that lacks TXLNA, researchers aim to uncover the mechanisms that regulate immune activation and how this may relate to autoimmune diseases like systemic lupus erythematosus. The findings could provide insights into new therapeutic targets for treating both autoimmune conditions and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases and improve cancer immunotherapy strategies.
How similar studies have gone: Previous research has shown promising results in understanding the cGAS-STING pathway, but the specific role of TXLNA in this context is still being explored.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Li, Shitao — Tulane University of Louisiana
- Study coordinator: Li, Shitao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.