Understanding how two bacteria interact during infections
Official title: Cooperation and antagonism in polymicrobial infection
Funded at Ohio State University · NIH-11103349 · Data updated 2026-11-12
This study looks at how two common bacteria, Pseudomonas aeruginosa and Staphylococcus aureus, interact with each other in the lungs of people with cystic fibrosis, hoping to find new ways to improve treatments for infections caused by these germs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 4, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $734,208 |
| NIH project number | 5R01AI186380-02 |
| Project ID | NIH-11103349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cystic fibrosis who experience chronic lung infections.
✕Less likely to help
Patients with infections caused by other pathogens not involving Pseudomonas aeruginosa or Staphylococcus aureus may not benefit from this research.
What this research studies
This research investigates the interactions between two common bacteria, Pseudomonas aeruginosa and Staphylococcus aureus, which often coexist in chronic infections, particularly in the lungs of individuals with cystic fibrosis. The study aims to explore how these bacteria compete and cooperate with each other, using various laboratory techniques to analyze their behaviors and the mechanisms behind their interactions. By understanding these dynamics, the research seeks to uncover new insights that could lead to better treatment strategies for infections caused by these pathogens.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from chronic infections caused by these bacteria.
How similar studies have gone: Previous research has shown promising results in understanding bacterial interactions, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Wozniak, Daniel J — Ohio State University
- Study coordinator: Wozniak, Daniel J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.