Understanding how tunneling nanotubes help viruses spread between cells
Official title: Deciphering the molecular mechanisms of TNT formation and function using a multi-omic approach
Funded at California State University Fresno · NIH-10767277 · Data updated 2026-11-12
This study is looking at tiny connections between cells called tunneling nanotubes to understand how they help spread viruses like HIV-1 and HTLV-1, which could lead to new ways to treat infections and diseases like cancer and neurodegenerative disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Fresno NIH-funded |
| Lab location | 1 site (Fresno, United States) |
| Project start | February 1, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $338,205 |
| NIH project number | 5SC1GM139732-04 |
| Project ID | NIH-10767277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with HIV-1 or HTLV-1, as well as those at risk for neurodegenerative diseases.
✕Less likely to help
Patients who do not have HIV-1, HTLV-1, or related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the role of tunneling nanotubes (TNTs), which are tiny structures that connect cells and facilitate the transfer of various molecules and pathogens. By using a multi-omic approach, the study aims to uncover the molecular mechanisms behind TNT formation and function, particularly in relation to viruses like HIV-1 and HTLV-1. The research will involve laboratory experiments to analyze how these structures contribute to the spread of infections and potentially influence cancer and neurodegenerative diseases. Patients may benefit from insights gained about how these mechanisms operate, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of viruses and improve outcomes for patients with related diseases.
How similar studies have gone: While the role of TNTs in cellular communication is an emerging field, similar studies have shown promising results in understanding their function in disease processes.
Where this research is happening
-
California State University Fresno
Fresno, United States Active
Researchers
- Principal investigator: Gousset, Karine — California State University Fresno
- Study coordinator: Gousset, Karine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.