Investigating how certain compounds can kill harmful parasitic worms
Nematicidal Chalcones: A Genetic Approach to Uncovering the Action Mechanism
This study is looking at how certain natural compounds called chalcones can help kill harmful worms that affect plants, animals, and even people, with the hope of finding new treatments for these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Fresno NIH-funded |
| Lab location | 1 site (Fresno, United States) |
| Project ID | NIH-11091563 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific compounds, known as chalcones, can effectively kill parasitic nematodes that affect both plants and animals, including humans. By using a genetic approach, the researchers aim to uncover the mechanisms through which these compounds operate, particularly in the model organism Caenorhabditis elegans. The study involves testing the effects of these compounds on nematodes and analyzing their interactions at the genetic level to identify potential new treatments for nematode infections. The ultimate goal is to develop effective nematicidal agents that can be used in agriculture and medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals affected by nematode infections or those involved in agriculture dealing with nematode-related crop losses.
Not a fit: Patients who are not affected by nematode infections or who do not work in agriculture may not receive any direct benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for nematode infections, benefiting agriculture and human health.
How similar studies have performed: Previous research has shown promise in using similar compounds for nematode control, indicating potential for success in this approach.
Where this research is happening
Fresno, United States
- California State University Fresno — Fresno, United States (Active)
Researchers
- Principal investigator: Calderon-Urrea, Alejandro — California State University Fresno
- Study coordinator: Calderon-Urrea, Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.