Understanding how tumors interact with the immune system in brain cancer
Image-based models of tumor-immune dynamics in glioblastoma
['FUNDING_U01'] · MAYO CLINIC ARIZONA · NIH-11047674
This study is looking at how brain tumors and the immune system interact in glioblastoma, and it uses advanced imaging and AI to help predict how each person's tumor might respond to immunotherapy, with the goal of finding better treatment options for patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ARIZONA (nih funded) |
| Locations | 1 site (SCOTTSDALE, UNITED STATES) |
| Trial ID | NIH-11047674 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamics between tumors and the immune system in glioblastoma, a type of brain cancer. By utilizing advanced imaging techniques and artificial intelligence, the study aims to create detailed models that can predict how individual tumors respond to immunotherapy. The approach involves analyzing MRI scans alongside biopsy data to capture the unique immune environment of each patient's tumor. This individualized understanding could lead to better treatment strategies and improved patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are considering or undergoing immunotherapy.
Not a fit: Patients with other types of brain tumors or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments tailored to individual patients with glioblastoma.
How similar studies have performed: Other research has shown promise in using imaging and computational models to understand tumor-immune interactions, indicating that this approach has potential for success.
Where this research is happening
SCOTTSDALE, UNITED STATES
- MAYO CLINIC ARIZONA — SCOTTSDALE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, LELAND — MAYO CLINIC ARIZONA
- Study coordinator: HU, LELAND
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer, anti-cancer research