Understanding how tubulin modifications affect cell organization
Official title: Feedback mechanisms link tubulin PTMs to Golgi organization
Funded at University of Michigan at Ann Arbor · NIH-11067977 · Data updated 2026-11-12
This study is looking at how a protein called tubulin affects the way cells are organized and function, especially in relation to movement and secretion, which could help us understand changes that happen in diseases like Alzheimer's.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32GM157897-01 |
| Project ID | NIH-11067977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or related dementias, as well as those experiencing abnormal tissue repair.
✕Less likely to help
Patients with conditions unrelated to cellular processes or those not affected by Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of tubulin, a key protein in cell structure, and how its modifications influence the organization of cellular components, particularly in relation to microtubules. By examining how cells select specific microtubules for these modifications, the study aims to uncover the mechanisms that drive important cellular processes like movement and secretion. The research employs biochemical and cell biology techniques to explore how mechanical signals can alter these processes, potentially leading to abnormal cell behavior. This work is crucial for understanding cellular functions that may be disrupted in diseases such as Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular dysfunctions associated with Alzheimer's disease and other conditions, potentially informing therapeutic strategies.
How similar studies have gone: While the specific mechanisms being studied are novel, there is a growing body of research indicating that understanding tubulin modifications can lead to significant advancements in cell biology and disease treatment.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Pimm, Morgan Lynn — University of Michigan at Ann Arbor
- Study coordinator: Pimm, Morgan Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.