Understanding how tuberculosis interacts with the immune system
Defining the antibody interface between Mycobacterium tuberculosis and host immunity
This study is looking at how certain antibodies in your body respond to the bacteria that causes tuberculosis (TB), and it wants to see how these responses differ between people who have a hidden (latent) form of TB and those who are actively sick, with the goal of finding better ways to diagnose and prevent TB.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10906759 on NIH RePORTER |
What this research studies
This research investigates the role of antibodies in the immune response to Mycobacterium tuberculosis, the bacteria that causes tuberculosis (TB). It focuses on how different types of antibodies, particularly IgG, interact with the immune system and how these interactions vary between individuals with latent TB and those with active disease. By studying these differences, the research aims to uncover important insights that could lead to better diagnostics and vaccines for TB. Patients may be involved in providing samples to help understand these immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of tuberculosis infection, whether latent or active.
Not a fit: Patients who do not have a history of tuberculosis or related infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and vaccines for tuberculosis, ultimately reducing the number of deaths caused by this disease.
How similar studies have performed: Previous research has shown promise in understanding immune responses to tuberculosis, but this specific approach focusing on antibody interactions is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Lu, Lenette — Ut Southwestern Medical Center
- Study coordinator: Lu, Lenette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.