Understanding how toxic substances affect ovarian function
In Vitro to In Vivo Extrapolation of Toxicant Effects on Ovarian Function
This study is looking at how harmful chemicals in our environment might affect women's ability to get pregnant by impacting their ovaries, and it aims to help improve fertility for those who are struggling with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11018514 on NIH RePORTER |
What this research studies
This research investigates the impact of environmental toxicants on ovarian function, particularly focusing on how these substances can impair the ability to conceive. By combining data from laboratory rodents and nonhuman primates, the study aims to create a more accurate understanding of how toxic exposures affect ovarian follicles, which are crucial for hormone production and egg viability. The research will involve forming a consortium of experts to analyze and model the physiological responses of ovarian follicles to various toxicants, ultimately aiming to improve fertility outcomes for women affected by these issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing infertility issues, particularly those who have been exposed to environmental toxins.
Not a fit: Patients who are not experiencing fertility issues or who have other underlying medical conditions unrelated to ovarian function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of infertility caused by environmental toxins, potentially improving fertility treatments for women.
How similar studies have performed: While there has been research on ovarian toxicity in laboratory rodents, this approach of integrating data from both rodents and nonhuman primates is relatively novel and has not been extensively tested.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Craig, Zelieann Rivera — University of Arizona
- Study coordinator: Craig, Zelieann Rivera
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.