Understanding how to induce tolerance in immune cells to prevent attacks on myelin in multiple sclerosis
Defining the induction and maintenance of myelin-specific tolerance in T cells and B cells using local lymph node depots
This study is looking at a new way to help the immune system recognize myelin, which protects the nerves, as something the body should keep rather than attack, with the hope of creating a better treatment for people with multiple sclerosis that could reduce the need for long-term medications that weaken the immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-11014439 on NIH RePORTER |
What this research studies
This research investigates how to train the immune system to recognize myelin, a protective substance in the nervous system, as a 'self' molecule rather than a foreign invader. By using a method that combines specific myelin peptides with signals that promote tolerance, the study aims to enhance the body's ability to control autoimmune responses without compromising overall immunity. The approach focuses on local lymph nodes, which are crucial for immune cell regulation, and explores how certain immune cells can be encouraged to adopt protective roles against multiple sclerosis. Patients may benefit from a more targeted therapy that could reduce the need for lifelong immunosuppressive treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis who are experiencing autoimmune attacks on myelin.
Not a fit: Patients with other neurological disorders unrelated to autoimmune mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for multiple sclerosis by promoting immune tolerance.
How similar studies have performed: Previous research has shown promise in using antigen-specific tolerance strategies in autoimmune diseases, indicating potential for success in this approach.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Jewell, Christopher M — Univ of Maryland, College Park
- Study coordinator: Jewell, Christopher M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.