Understanding how tip link proteins affect hearing function
Official title: Investigating the role of tip link biophysics on MET function
Funded at Massachusetts Eye and Ear Infirmary · NIH-11070464 · Data updated 2026-11-12
This study is looking at special proteins in the tiny hair cells in your ears that help you hear and keep your balance, to see how they react to sounds and movements, which could help us find new ways to treat hearing loss.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 29, 2024 |
| Project end | August 28, 2027 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32DC022491-01 |
| Project ID | NIH-11070464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing hearing loss or related auditory disorders.
✕Less likely to help
Patients with non-auditory conditions or those not affected by hearing loss may not benefit from this research.
What this research studies
This research investigates the role of tip link proteins in hair cells, which are crucial for hearing and balance. By examining how these proteins respond to mechanical stimuli like sound and movement, the study aims to uncover their impact on the opening of channels that allow ions to enter hair cells. The research utilizes animal models to explore these mechanisms, particularly focusing on the proteins protocadherin 15 and cadherin 23. This approach could lead to a better understanding of hearing processes and potential therapies for hearing loss.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hearing loss by enhancing our understanding of the mechanisms involved in auditory function.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar proteins in auditory function, indicating that this approach has potential for success.
Where this research is happening
-
Massachusetts Eye and Ear Infirmary
Boston, United States Active
Researchers
- Principal investigator: Yeh, Frank — Massachusetts Eye and Ear Infirmary
- Study coordinator: Yeh, Frank
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.