Understanding how tiny vesicles affect inflammation during pneumonic plague
Defining the impact of Extracellular Vesicles on inflammation during pneumonic plague
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF LOUISVILLE · NIH-10983732
This study is looking at tiny particles called extracellular vesicles that help immune cells talk to each other during pneumonic plague, a serious infection, to find out how they can either help or hinder the body's response, which could lead to better ways to boost our immune defenses against infections.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-10983732 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular vesicles (EVs) in the immune response during pneumonic plague, a severe bacterial infection caused by Yersinia pestis. By examining how these vesicles facilitate communication between immune cells, the study aims to uncover mechanisms that either promote or suppress inflammation. The research will involve analyzing the biochemical properties of EVs and their impact on the immune system's ability to respond to the infection. Patients may benefit from insights gained into how to enhance immune responses against bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently experiencing severe bacterial infections, particularly pneumonic plague.
Not a fit: Patients with non-bacterial infections or those who do not have a compromised immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving immune responses in patients suffering from severe bacterial infections.
How similar studies have performed: Previous research has shown promising results in understanding immune responses through the study of extracellular vesicles, indicating that this approach has potential for significant findings.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHENEMAN, KATELYN RENEE — UNIVERSITY OF LOUISVILLE
- Study coordinator: SHENEMAN, KATELYN RENEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections