Understanding how thymic B cells contribute to immune tolerance
Official title: Role of thymic B cells in immune tolerance
Funded at University of Minnesota · NIH-10947644 · Data updated 2026-11-12
This study is looking at how certain immune cells called thymic B cells help keep our immune system in check to prevent autoimmune diseases, which could lead to new ways to understand and treat these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 12, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $138,051 |
| NIH project number | 1K99AI184587-01 |
| Project ID | NIH-10947644 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those at risk of developing such conditions.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by immune tolerance issues may not benefit from this research.
What this research studies
This research investigates the role of thymic B cells in the development of immune tolerance, which is crucial for preventing autoimmune diseases. It focuses on how these B cells interact with T follicular regulatory cells to regulate immune responses and prevent the formation of harmful autoantibodies. By studying the mechanisms of T cell receptor selection and the effects of thymic B cells on T cell development, the research aims to uncover new insights into immune regulation. Patients may benefit from a better understanding of autoimmune conditions and potential new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases by enhancing our understanding of immune tolerance mechanisms.
How similar studies have gone: Other research has shown promising results in understanding immune tolerance mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Martinez, Ryan J — University of Minnesota
- Study coordinator: Martinez, Ryan J
Related research
Other NIH-funded projects on the same topics.
-
Investigating biological markers related to human reproduction and development
This study is looking at how different factors in our bodies affect reproduction and the health of children and teens, and it's for anyone interested in understanding more about these important topics by analyzing samples like blood and urine without changing anything in their daily lives.
-
AI-powered liver cancer screening using ultrasound blood flow patterns
A new AI-based method analyzes liver blood flow signals to help detect liver cancer early in people with liver disease, especially in settings with limited resources.
-
Caregiver-led mobile tool to support healthy habits for kids treated for ALL
A caregiver-directed mobile program helps children who were treated for acute lymphoblastic leukemia build healthier daily routines.
-
Understanding how survivorship care plans affect health outcomes for cancer survivors
A study will look at whether survivorship care plans help reduce deaths and improve health for adults who have survived cancer.
-
Understanding the experience of ovarian cancer after diagnosis to improve survivorship
This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.
-
Minnesota Population Center: a hub for migration, family and community data science
A university research center helps researchers study population dynamics by sharing data, training researchers, and communicating findings to diverse audiences.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.