Understanding how thrombospondin-1 helps prevent abdominal aortic aneurysm rupture
Novel Role of Thrombospondin-1 in Protection against Rupture of Abdominal Aortic Aneurysm
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10823253
This study is looking at how a protein called thrombospondin-1 helps protect against the dangerous bursting of abdominal aortic aneurysms, which can be life-threatening, and it aims to find out how certain immune cells are involved in this process, with hopes of discovering new ways to prevent aneurysm ruptures in patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10823253 on ClinicalTrials.gov |
What this research studies
This research investigates the role of thrombospondin-1 (TSP1) in protecting against the rupture of abdominal aortic aneurysms (AAA), a serious condition that can lead to life-threatening complications. By using advanced techniques like single-cell RNA sequencing, the study aims to identify how specific immune cells, particularly macrophages, contribute to the levels of TSP1 in the aorta. The researchers will create genetically modified mice to observe the effects of TSP1 deletion on aneurysm development and rupture, providing insights into the underlying mechanisms of AAA. This could lead to new therapeutic strategies to prevent aneurysm rupture in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for abdominal aortic aneurysms, particularly those with a history of cardiovascular disease or genetic predispositions.
Not a fit: Patients who do not have abdominal aortic aneurysms or related vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of abdominal aortic aneurysm rupture, improving patient survival rates.
How similar studies have performed: Previous research has shown promising results in understanding the role of thrombospondin-1 in vascular conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, BO — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: LIU, BO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease