Understanding how the X-chromosome affects brain function in adult women
Official title: Decoding the X-chromosome Dynamics in the Adult Female Brain
Funded at Fordham University · NIH-11031430 · Data updated 2026-11-12
This study looks at how changes in female hormones affect the brain and behavior in adult females, using mice to find out if certain genes on the X-chromosome play a role in conditions like anxiety and depression, which could help us understand more about women's mental health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fordham University NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | February 8, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $170,773 |
| NIH project number | 5R21MH136483-02 |
| Project ID | NIH-11031430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult women experiencing anxiety or depression, particularly those interested in the biological factors influencing their conditions.
✕Less likely to help
Patients who are not adult females or those without anxiety or depression may not benefit from this research.
What this research studies
This research investigates the role of the X-chromosome in the brain of adult females, particularly how fluctuations in ovarian hormones influence brain structure and behavior. By studying mouse models, the researchers aim to identify specific genes on the X-chromosome that may escape inactivation and contribute to neuropsychiatric disorders like anxiety and depression. The project will explore how these genetic dynamics change throughout the estrous cycle, potentially impacting gene expression and behavior. This could provide insights into the unique neurobiological factors affecting women's mental health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for anxiety and depression in women.
How similar studies have gone: While the specific dynamics of X-chromosome behavior in relation to ovarian hormones are less explored, similar research has shown promising results in understanding sex differences in neuropsychiatric disorders.
Where this research is happening
-
Fordham University
Bronx, United States Active
Researchers
- Principal investigator: Kundakovic, Marija — Fordham University
- Study coordinator: Kundakovic, Marija
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.