Understanding how the tumor environment affects colorectal cancer
Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer
This study is looking at how different cells in the environment around colorectal cancer tumors interact with each other, especially in a tough-to-treat type of cancer, to find new ways to help patients feel better and improve their treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911847 on NIH RePORTER |
What this research studies
This research investigates the interactions within the tumor microenvironment (TME) of colorectal cancer (CRC) to better understand how these cellular interactions influence cancer progression. Using advanced mouse models that mimic human disease, the research team will analyze the metabolic and inflammatory processes at a single-cell level. The goal is to uncover the molecular mechanisms that drive a specific aggressive type of CRC, known as mesenchymal CRC, which has a poor prognosis. This work aims to provide insights that could lead to new therapeutic strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with the mesenchymal subtype.
Not a fit: Patients with early-stage colorectal cancer or those without the mesenchymal subtype may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with colorectal cancer.
How similar studies have performed: Previous research has shown promise in understanding the tumor microenvironment in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Duran Molina, Maria Angeles — Weill Medical Coll of Cornell Univ
- Study coordinator: Duran Molina, Maria Angeles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.